Build a pipeline of tumor adaptation
inhibitors and biomarkers
to stop cancer growth over time
Metabolic Adaptation is Essential for Cancer
Metabolic adaptation is a hallmark of cancer1
Ensures supply of nutrients to cancer cells
Enables them to grow aggressively and resist to therapy
1. D. Hanahan, Cell (2011) & Cancer Discovery (2022)
The science is based on our unique ability to identify cancer molecular vulnerabilities, with unique animal models which have a high genetic overlap with human cancers, and the ability to assess response and adaptation to treatment with high reproducibility of clinical response observed in patients. This platform identifies treatment induced escape mechanisms in resistance to treatment that are also applicable to naïve tumors.
The novelty and the potential impact of the AtG project has been recognized by several entities at a national and international level.